• Bachelor of Pharmacy, Addis Ababa University, 1984.
• MSc, Pharmacology, Addis Ababa University, 1997.

• Ph.D., Pharmacology, University of  Vienna,  2002.
• Certificate of competence in Higher education management: University of Witwatersrand, 2010.

Adjunct Associate Professor (2013, Howard University, USA)

Building name: College of Health Sciences

Floor number: 2

Office room no. 8

Office tel.

Mobile: +251-911-408336

University email ID: ephrem.engidawork@aau.edu.et

Alternative email ID: ephrem.engidawork@gmail.com

1. Asrade S. Shibeshi W, Engidawork E. (2013): Evaluation of the reversibility and possible mechanisms of antifertility of Catha edulis F. (khat) extract following subacute administration in rodents. African Journal of Pharmacy and Pharmacology 7: 2693-2700.
2. Ibrahim M, Engidawork E, Yimer G, Bobosha K, Aseffa A. (2013): Pharmacokinetics of isoniazid in Ethiopian children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype. African Journal of Pharmacy and Pharmacology 7: 1124-1130.
3. Kimmo JD, Hisham E, Engidawork E, Aboye T, Goransson U, Hellman B. (2013): An in vitro study on the DNA damaging effects of phytochemicals partially isolated from an extract of Glinus lotoides. Phytotherapy Research 27: 507-514.
4. Ashenef S, Engidawork E. (2013): Fluoride levels and its safety in Tea (Camellia sinensis) and Khat (Catha edulis) imported and produced in Ethiopia. Ethiopian Journal of Environmental Studies and Management 6: 149-158.
5. Feyissa T, Asres K, Engidawork (2013): Renoprotective effects of the crude extract and solvent fractions of the leaves of Euclea divinorum H. against gentamicin-induced nephrotoxicity in rats. Journal of Ethnopharmacology 145: 758-766.
6. Mekonnen A, Sidamo T, Asres K, Engidawork (2013): In vivo wound healing activity and phytochemical screening of the crude extract and various fractions of Kalanchoe petitiana A. Rich (Crassulaceae) leaves in mice. Journal of Ethnopharmacology 145: 638-646.
7. Tamiru W, Engidawork E, Asres K. (2012): Evaluation of the effects of 80% methanolic leaf extract of Caylusea abyssinica (fresen.) fisch. & Mey. On glucose handling in normal, glucose loaded and diabetic rodents. BMC Complementary and Alternative Medicine 12: 151.
8. Admassie E, Engidawork E. (2011) Subchronic administration of Catha edulis F. (khat) extract is marked by elevation of cardiac biomarkers and subendocardial necrosis besides blood pressure alteration in rats. Journal of Ethnopharmacology 136: 246-253.
9. Mohammed A., Engidawork E. (2011): Outcomes of khat extract and cathinone on reproductive parameters of male rats. Journal of Ethnopharmacology 134: 977-983.
10. Melese E., Asres K., Asad M., Engidawork E. (2011). Evaluation of the antipeptic ulcer activity of the leaf extract of Plantago lanceolata in rodents. Phytotherapy Research 25: 1174-1180.
11. Gebeyehu E, Engidawork E, Bijinsdorp A, Armin A, Diczfalusy, Aklillu E. (2011). Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians. The Pharmacogenomics Journal 11: 13-137.
12. Geresu E, Engidawork E (2010): Catha edulis (khat) reverses haloperidol but not morphine induced motor deficits following acute and subacute administration in mice. Ethiopian Pharmaceutical Journal 28: 117-130.
13. Wolde T, Engidawork E, Asres K, Eregete W. (2010) Evaluation of hepatoprotective activities of Satureja punctata Benth Briq and Solanecio angulatus Vahl Jeffrey in ferric nitrillotriacetate induced hepatotoxicity in rats. Ethiopian Pharmaceutical Journal 28: 63-74.
14. Ayele Y., Urga K., Engidawork E. (2010): Evaluation of in vivo antihypertensive and in vitro vasodepressor activities of the leaves extract of syzygium guineense (willd) DC. Phytotherapy Research 24: 1457-1462.
15. Abera K, Gedif T, Engidawork E, Gebre-Mariam T. (2010). Quality of life of people living with HIV/AIDS and on highly active antiretroviral therapy in Ethiopia. African Journal of AIDS Research 9: 31-40.
16. Mekonnen T., Urga K., Engidawork E. (2010): Evaluation of the diuretic and analgesic activities of the rhizomes of Rumex abyssinicus Jacq in mice. Journal of Ethnopharmacology 127: 433-439.
17. Bedada W, Engidawork E. (2010): The neuropsychopharmacological effects of Catha edulis in mice offspring born to mothers exposed during pregnancy and lactation. Phytotherapy Research 24: 268-276.
18. Teshome K, Gebre-Mariam T, Asres K, Perry F, Engidawork E. (2010) Toxicity studies on dermal application of Dodonea viscosae used in traditional medicine. Phytotherapy Research 24: 60-69.
19. Beyene K.A., Gedif T., Gebre-Mariam T, Engidawork E. (2009): Highly active antiretroviral therapy adherence and its determinants in selected hospitals from south and central Ethiopia. Journal Pharmacoepidemology and Drug Safety 18: 1007-1015.
20. Demma J., Engidawork E., Hellman B. (2009) Potential genotoxicity of plant extracts used in Ethiopian traditional medicine. Journal of Ethnopharmacology 122: 136-142.
21. Ahmed K, Ayana G, Engidawork E. (2008) Lead exposure study workers in lead acid battery repair units of transport service enterprises, Addis Ababa, Ethiopia; a cross-sectional study. Journal of Occupational Medicine and  Toxicology 3:
22. Teshome K, Gebre-Mariam T, Asres K, Perry F, Engidawork E. (2008) Toxicity studies on dermal application of Plumbago zeylanica used in traditional medicine. Journal of Ethnopharmacology 117: 236-248.
23. Gulesserian T, Engidawork E, Fountoulakis M, Lubec G. (2007) Manifold decrease of sialic acid synthase in fetal Down syndrome brain. Amino Acids 32: 141-144.
24. Demma J., Gebre-Mariam T, Asres K, Ergetie W, Engidawork E. (2007) Toxicological study on Glinus lotoides: A traditionally used taenicidal herb in Ethiopia. Journal of Ethnopharmacology 111: 451-457.
25. Hoeger H, Engidawork E, Stolzlechner D, Bubna-Littitz H, Lubec B. (2006) Long-term effect of moderate and profound hypothermia on morphology, neurological, cognitive and behavioural functions in a rat model of perinatal asphyxia. Amino Acid 31: 385-396.
26. Engidawork E, Afjehi-Sadat L, Yang JW, Slavc I, Lubec G. (2006) Protein chemical identification and characterization of the human variants of far upstream element binding protein in medulloblastoma DAOY cell line. International Journal of Oncology 29: 721-736.
27. Yang JW, Kang SU, Engidawork E, Rodrigo R, Felipo V, Lubec G. (2006) Mass spectrometrical analysis of galectin proteins in primary rat cerebellar astrocytes. Neurochemistry Research 31: 945-55.
28. Afjehi-Sadat L, Engidawork E, Slavc I, Lubec G. (2006) Comparative proteomic analysis of nucleic acid-binding proteins in ten human tumor cell lines. International Journal of Oncology 28: 173-90.
29. Oh JE, Engidawork E, Shin JH, Lubec G. (2005) Specific expression of potential tumor marker proteins, similar to No On or off transient A and HIRA-interacting protein 5 in mouse N1E-115 neuroblastoma cell line. Cancer Genomics and Proteomics 2: 209-218.
30. Shin J-H, Engidawork E, Delabar J-M, Lubec G. (2005) Identification and characterization of soluble epoxide hydrolase in mouse brain by a robust protein biochemical method. Amino Acid 28: 63-69.
31. Hepner F, Engidawork E, Ulfig N, Lubec G. (2005) Protein chemical identification and characterization of DJ-1 protein in human fetal brain: a tool for better understanding of DJ-1’s biological role. Neuroembriology 3: 60-64.
32. Engidawork E, Lubec G (2004) Proteomic approaches contributing to the understanding of neurodegenerative diseases: Focus on Alzheimer’s disease. Current Proteomics 1: 221-229.
33. Weizdeorfer R, Hoeger H, Engidawork E, Engelmann M, Singewald N, Lubec G, Lubec B. (2004) Neuronal nitric oxide synthase knockout mice show impaired cognitive performance. Nitric Oxide 10: 130-140.
34. Afjehi-Sadat L, Engidawork E, Slavi I, Lubec G. (2004) Proteomic profiling of signaling proteins in ten different tumor cell lines. Cancer Genomics and Proteomics 1: 417-454.
35. Engidawork E, Lubec G (2003) Molecular changes in fetal Down syndrome brain. Journal of Neurochemistry 84: 895-904.
36. Engidawork E, Gulesserian T, Fountoulakis M, Lubec G (2003) Expression of hypothetical proteins in human fetal brain: increased expression of hypothetical protein 25.8 kDa in Down syndrome, a clue for its tentative role. Molecular Genetics and  Metabolism 78: 295-301.
37. Engidawork E, Gulesserian T, Fountoulakis M, Lubec G (2003) Aberrant protein expression in cerebral cortex of fetus with Down syndrome. Neuroscience 122: 145-154.
38. Krabpfenbauer K, Engidawork E, Fountoulakis M, Cairns N, Lubec G (2003) Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders. Brain Research 967: 152-160.
39. Gulesserian T, Engidawork E, Fountoulakis M, Lubec G (2003) Decreased brain levels of La Lupus protein and increased U5-small nuclear ribonuclearproteins-specific 40 kDa protein indicate impaired transcription/translation in fetal Down syndrome. Cell and Molecular Biology 49: 733-738.
40. Salchner P., Engidawork E., Hoeger H., Lubec B. and Singewald N. (2003) Perinatal asphyxia exerts lifelong effects on neuronal responsiveness to stress in specific brain regions in the rat. Journal of Investigative Medicine 51: 288-294.
41. Weitzdoerfer R, Gerstl N, Hoeger H, Mosgoeller W, Dreher W, Engidawork E, Overgaard-Larsen J, Lubec B (2002) Long-term sequelae of perinatal asphyxia in the aging rat. Cell and Molecular Life Science 59: 519-526.
42. Lubec G, Engidawork E (2002) The brain in Down syndrome (Trisomy 21) Journal of Neurology 249: 1347-1356.
43. Engidawork E, Lubec G (2001) Protein expression in Down syndrome. Amino Acids 21: 331-361.
44. Engidawork E, Gulesserian T, Yoo B.C, Cairns N, Lubec G (2001) Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer’s disease. Biohemical and Biophysicak Research Communication 281: 84-93.
45. Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001) Expression of apoptosis-related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-kB in brains of patients with Down syndrome. Journal of Neural Transmission 61: 181-192.
46. Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001) Expression of apoptosis-related proteins in brains of patients with Alzheimer’s disease. Neuroscience Letters 303: 79-82.
47. Engidawork E, Balic N, Juranville J-F, Fountoulakis M, Dierssen M, Lubec G (2001) Unaltered expression of Fas (CD95/APO), Caspase-3, Bcl-2 and Annexins in brains of fetal Down syndrome. Evidence against increased apoptosis. Journal of Neural Transmission 61: 149-162.
48. Engidawork E, Loidl F, Chen Y, Kohlhauser C, Stoeckler S, Dell’Anna E, Lubec B, Lubec G, Goiny M, Gross J, Andersson K, Herrera-Marschitz (2001) Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia. Experimental Brain Research 138: 375-383.
49. Engidawork E, Juranville J-F, Fountoulakis M, Dierssen M, Lubec G (2001) Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. Journal of Neural Transmission 61: 117-130.
50. Engidawork E, Balic N, Fountoulakis M, Dierssen M, Lubec G (2001) ß-amyloid precursor protein, ETS-2 and collagen type VI chain precursor encoded on chromosome 21 are not overexpressed in fetal Down syndrome. Evidence against the gene dosage effect. Journal of Neural Transmission 61: 335-346.
51. Engidawork E, Gulesserian T, Zadic N, Cairns N, Lubec G (2001) Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer’s disease. Journal of Neural Transmission 61: 211-222.
52. Engidawork E, Roberts JC, Hardmeier R, Scheper RJ, Lubec G (2001) Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains Journal of Neural Transmission 61: 35-45.
53. Gulesserian T, Engidawork E, Fountoulakis M, Lubec G (2001) Antioxidant proteins in fetal brain: Superoxide dismutase-I (SOD-1) protein is not overexpressed in fetal Down syndrome. Journal of Neural Transmission 61: 71-84.
54. Yoo BC, Vlkolnisky R, Engidawork E, Cairns N, Fountoulakis M, Lubec G (2001) Differential expression of molecular chaperones in brains of patients with Down syndrome. Electrophoresis 22: 1233-1241.
55. Gulesserian T, Engidawork E, Yoo BC, Cairns N, Lubec G (2001) Alteration of caspases and their regulatory proteins in brains of Down syndrome. Journal of Neural Transmission 61: 163-179.
56. Gulesserian T, Engidawork E, Cairns N, Lubec G (2000) Increased serotonin protein levels in frontal cortex of patients with Down syndrome. Neuroscience Letters 296: 53-57.
57. Herrera-Marschitz M, Goiny M, You ZB, Meana JJ, Engidawork E, Chen Y, Rodriguez-Puertas R, Broberger C, Andersson K, Terenius L, Hokfelt T, Ungerstedt U. (1998) Release of endogenous excitatory amino acids in the neostriatum of the rat under physiological and pharmacologically-induced conditions. Amino Acid 14: 197-203.
58. Engidawork E, Chen Y, Dell’anna E, Goiny M, Lubec G, Ungrestedt U, Andersson K, Herrera-Marshitz M (1997) Effect of perinatal asphyxia on systemic and intracerebral pH and glycolysis metabolism in rats. Experimental Neurology 145: 390-396.
59. Chen Y, Engidawork E, Loidl F, Dell’Anna E, Goiny M, Lubec G, Andersson K, Herrera-Marschitz M (1997) Short and Long-term effects of perinatal asphyxia on monoamine, amino acid, glycolysis product levels measured in the basal ganglia of the rat. Developmental Brain Research 104: 19-30.
60. Dell’anna D, Chen Y, Engidawork E, Andersson K, Lubec G, Luthman J, Herrera-Marshitz M (1997) Delayed neuronal death following perinatal asphyxia in rat. Experimental Brain Research 115: 105-115.